Adrenergic receptors modulate motoneuron excitability , sensory synaptic 1 transmission and muscle spasms after chronic spinal cord injury
نویسنده
چکیده
Adrenergic receptors modulate motoneuron excitability, sensory synaptic 1 transmission and muscle spasms after chronic spinal cord injury. 2 Rank MM, Murray KC, Stephens MJ, D’Amico J, Gorassini MA, and Bennett DJ 3 Centre for Neuroscience, University of Alberta, Edmonton, Alberta, Canada 4 5 6 Running Title: Adrenergic receptors modulate spasms. 7
منابع مشابه
Adrenergic receptors modulate motoneuron excitability, sensory synaptic transmission and muscle spasms after chronic spinal cord injury.
The brain stem provides most of the noradrenaline (NA) present in the spinal cord, which functions to both increase spinal motoneuron excitability and inhibit sensory afferent transmission to motoneurons (excitatory postsynaptic potentials; EPSPs). NA increases motoneuron excitability by facilitating calcium-mediated persistent inward currents (Ca PICs) that are crucial for sustained motoneuron...
متن کاملMuscle Spasms After Chronic Spinal Cord Injury Excitability, Sensory Synaptic Transmission and Adrenergic Receptors Modulate Motoneuron
[PDF] [Full Text] [Abstract] , April , 2011; 105 (4): 1835-1849. J Neurophysiol Brian R. Noga, Dawn M. G. Johnson, Mirta I. Riesgo and Alberto Pinzon receptors in the thoraco-lumbar spinal cord 2b α or NE 1a α with NE Locomotor-activated neurons of the cat. II. Noradrenergic innervation and colocalization [PDF] [Full Text] [Abstract] , October , 2011; 106 (4): 1652-1661. J Neurophysiol Tany...
متن کاملNeuronal Mechanisms of Hyperexcitability in Individuals with Spasticity after Spinal Cord Injury and Individuals with Bruxism
Motoneuron hyperexcitability is a characteristic of several different motor disorders. We examined neuronal mechanisms of hyperexcitability in two of these disorders: spasticity after spinal cord injury (SCI) and bruxism. Involuntary muscle spasms after SCI occur as a result of uncontrolled increases in motoneuron excitability. Brainstem-derived serotonin (5HT) and noradrenaline (NA) normally f...
متن کاملPolysynaptic excitatory postsynaptic potentials that trigger spasms after spinal cord injury in rats are inhibited by 5-HT1B and 5-HT1F receptors.
Sensory afferent transmission and associated spinal reflexes are normally inhibited by serotonin (5-HT) derived from the brain stem. Spinal cord injury (SCI) that eliminates this 5-HT innervation leads to a disinhibition of sensory transmission and a consequent emergence of unusually long polysynaptic excitatory postsynaptic potentials (EPSPs) in motoneurons. These EPSPs play a critical role in...
متن کاملReduction of spinal sensory transmission by facilitation of 5-HT1B/D receptors in noninjured and spinal cord-injured humans.
Activation of receptors by serotonin (5-HT1) and norepinephrine (α2) on primary afferent terminals and excitatory interneurons reduces transmission in spinal sensory pathways. Loss or reduction of descending sources of serotonin and norepinephrine after spinal cord injury (SCI) and the subsequent reduction of 5-HT1/α2 receptor activity contributes, in part, to the emergence of excessive motoneu...
متن کامل